Nanobacteria 2005

A recent study of 15 men alleges great success in treating chronic prostatitis by treating nanobacteria. All the men in the study had prostatic calculi, and the study reports resolution of calcification of the prostate in some of the men. Mean patient age was 44.6 years.

Nanobacteria are the smallest known bacteria. They are Gram-negative and are associated with stones and calcifications in the urinary tract.

The Study

ANTI-NANOBACTERIAL THERAPY FOR MEN WITH CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME AND PROSTATIC STONES: PRELIMINARY EXPERIENCE
The Journal of Urology: Volume 173(2) February 2005 pp 474-477. By SHOSKES, DANIEL A.; THOMAS, KIM D.; GOMEZ, EYDA.

The lead author has financial interests or other relationships with ACMI, Roche, Farr Labs and Nanobac Life Sciences.

16 men with refractory chronic pelvic symptoms were studied. The men received 500 mg tetracycline, a proprietary nutraceutical and an ethylenediaminetetraacetic (EDTA) acid suppository daily. The men were treated for 3 months, with one patient being lost to follow-up.

8 of the patients (53%) experienced 50 percent improvement and a total of 12 patients (80%) had at least 25% improvement in symptoms.

Nanobacterial antigen or antibody was found in 60% of the patients’ serum and was found in 40% of the patients’ urine samples.

Most interesting is that the study reported that in 10 patients who underwent transrectal ultrasound (TRUS) after therapy prostatic stones were decreased in size or resolved in 50%.

Apparently, in a study done treating patients with the same regimen for coronary artery disease, several patients reported that their chronic prostatitis resolved. This led to doing the same treatment on chronic prostatitis patients who were resistant to other therapies and who had had documented prostatic stones.

Treatment received at bedtime consisted of three things:

1) 500 mg tetracycline orally

2) nanobacOTC supplement (Nanobac Life Sciences), a proprietary blend of vitamin C, selenium, EDTA, coenzyme Q10, bromelain, grapeseed extract, hawthorn berry, quercetin, L-arginine, vitamins B3, B6 and B9, L-lysine, L-ornithine, trypsin and papain)

3) a rectal suppository containing 1,500 mg EDTA.

Prostatitis

The study reports: “Using a definition of EPS inflammation of at least 10 white blood cells per high power field 7 men had category IIIa (inflammatory) and 8 had category IIIb disease.”

Nanobacteria Testing

The results of tests for nanobacteria are interesting, as the study reports: “Nine men (60%) had nanobacterial antigen or antibody detected in the blood, 6 (40%) had nanobacterial antigen in the urine and none had detectable levels in EPS.” The study goes on to say: “The lack of nanobacterial antigen detected in EPS was likely due to a limitation of the urine assay, which requires capillary action to pull the fluid through the development chamber, an action that viscous EPS could not provide.”

The study was small, but there seemed to be an association between being positive for nanobacteria and improvement of symptoms. Ten of the 12 patients who improved had nanobacteria detected in the blood or urine. The amount of calcification present did not seem to matter when it came to symptom improvement. Interestingly, ten patients underwent transrectal ultrasound (TRUS) after treatment and the stones were unchanged in size in 4, decreased in 5, and completely resolved in 1.

Stopping Therapy

The patients were treated for 3 months. After stopping therapy 2 patients had their symptoms return, which resolved again after restarting therapy. 7 patients had no worsening or recurrence of symptoms after stopping therapy.

Calculi and Symptoms

The authors hypothesize that the key factor in symptoms may be obstruction of prostatic ducts and acini.

Nanobacteria Tests

The company, Nanobac, has identified two biomarkers of nanobacterial infection which are NB2(TM) ELISA assays to detect nanobacterial antigen and IgG antibody.

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Copyright © 2005 by Bradley Hennenfent, M.D.
Written for www.ProstatitisAndBPH.org
January 13, 2005.